Tuesday, September 24, 2013

Flies & muscle atrophy--recent review

Piccirillo R, Demontis F, Perrimon N, Goldberg AL. Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn. 2013 Aug 29. PMID: 24038488.

The fly & retinal degeneration--recent review

Xiong B, Bellen HJ. Rhodopsin homeostasis and retinal degeneration: lessons from the fly. Trends Neurosci. 2013 Sep 5. PMID: 24012059.

From the abstract: "We review here the molecular signals involved in Rh homeostasis and the mechanisms underlying retinal degeneration in flies, and discuss possible links to human diseases."

Fly models & neurodevelopmental disorders--recent review

Okray Z, Hassan BA. Genetic approaches in Drosophila for the study neurodevelopmental disorders. Neuropharmacology. 2013 May;68:150-6. PMID: 23067575.

From GWAS to functional genetics--fly study related to diabetes and metabolism

Pendse J, Ramachandran PV, Na J, Narisu N, Fink JL, Cagan RL, Collins FS, Baranski TJ. A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. BMC Genomics. 2013 Feb 27;14:136. PMID: 23445342; PMCID: PMC3608171.

Two recent fly reports related to neurodegenerative diseases

Richards RI, Samaraweera SE, van Eyk CL, O'Keefe LV, Suter CM. RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases. Front Mol Neurosci. 2013 Sep 5;6:25. PMID: 24046729; PMCID: PMC3763583.

Lenz S, Karsten P, Schulz JB, Voigt A. Drosophila as a screening tool to study human neurodegenerative diseases. J Neurochem. 2013 Sep 12. PMID: 24028575.

Fly models in action--study related to Fragile X syndrome

Friedman SH, Dani N, Rushton E, Broadie K. Fragile X mental retardation protein regulates trans-synaptic signaling. Dis Model Mech. 2013 Sep 5. PMID: 24046358.

New fly model--Pantothenate Kinase-Associated Neurodegeneration

Varun P, Hagit T, Uriya B, Sagiv S, Sebastian K. A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Front Cell Neurosci. 2013 Sep 9;7:146. PMID: 24058333.