Relevant review--fly model & host defense

Ferrandon D. The complementary facets of epithelial host defenses in the genetic model organism Drosophila melanogaster: from resistance to resilience. Curr Opin Immunol. 2013 Feb;25(1):59-70. Review. PMID: 23228366.

Review includes discussion of fly models of fungal infection

Arvanitis M, Glavis-Bloom J, Mylonakis E. Invertebrate models of fungal infection. Biochim Biophys Acta. 2013 Sep;1832(9):1378-83. PMID: 23517918.

From the abstract: "The purpose of this review is to compare several model hosts that have been used in experimental mycology to-date and to describe their different characteristics and contribution to the study of fungal virulence and the detection of compounds with antifungal properties."

New fly model--pythiosis

Zanette RA, Santurio JM, Loreto ES, Alves SH, Kontoyiannis DP. Toll-deficient Drosophila is susceptible to Pythium insidiosum infection. Microbiol Immunol. 2013 Jul 19. PMID: 23865688.

From the abstract: "There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals that has poorly understood immunopathogenesis. We developed a pythiosis model ..."

Flies & infection.

Ben-Ami R, Watson CC, Lewis RE, Albert ND, Arias CA, Raad II, Kontoyiannis DP. Drosophila melanogaster as a model to explore the effects of methicillin-resistant Staphylococcus aureus strain type on virulence and response to linezolid treatment. Microb Pathog. 2013 Feb;55:16-20. PMID: 23232438.

Diaz L, Kontoyiannis DP, Panesso D, Albert ND, Singh KV, Tran TT, Munita JM, Murray BE, Arias CA. Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus. J Infect Dis. 2013 Jul;208(1):83-91. PMID: 23547139; PMCID: PMC3666140.


See also this post.